Gay activism collided with Hollywood as the Gay & Lesbian Alliance Against Defamation (GLAAD) rolled out the second event for its 20th annual Media Awards in Los Angeles Saturday.

The gay rights organization singled out Reverend Gene Robinson and comedians Kathy Griffin and Ellen DeGeneres at the star-studded show.

DeGeneres' daytime talk show, The Ellen DeGeneres Show, won a special prize for its episode featuring DeGeneres' marriage to actress Portia de Rossi.

Openly lesbian DeGeneres told the crowd at the Nokia Theatre, “In my opinion, we are not fighting for gay rights, we are fighting for equal rights,” and dedicated the honor to Carl Walker-Hoover, an 11-year-old boy who committed suicide after being bullied and called “gay” by students at his Massachusetts school.

Milk, Director Gus Van Sant's biopic about the life and times of slain gay rights pioneer Harvey Milk, won Outstanding Film.

On the small screen, ABC cleaned up with its Sunday lineup: Desperate Housewives won Outstanding Comedy Series, while Brothers and Sisters won in the Outstanding Drama Series category.

Politics and gay activism were on the minds of everyone attending the celebrity-lined bash.

"A lot of the messages that really affect the world and change people's minds come from Hollywood. Tonight, we're coming together and maybe we can change people's minds about the way gay people are treated," said openly gay actor Alan Cumming. "This is like the Oscars for gayness."

Self-described D-list celebrity herself, Kathy Griffin, got a bit of A-list pampering as she took home the Vanguard Award for her support of the lesbian, gay, bisexual and transgender community.

“I'm here to learn as well as be adored,” Griffin said. “And I'm already having a gay old time.”

Reverend Gene V. Robinson, the first openly gay Episcopal bishop, was also honored for his work as a religious leader and activist.

Last month, at a similar GLAAD event, financial guru Suze Orman, media personality Phil Donahue and supermodel Tyra Bank were honored in New York City. A final presentation in May will be held in San Francisco.