Out comedian Rosie O'Donnell on Wednesday launched a nearly two-minute rant against Donald Trump, the presumed Republican presidential nominee.

According to the Daily Mail, O'Donnell blasted Trump during an appearance at the Beacon Theatre in New York City.

O'Donnell joked that she was depressed because she hates “that orange piece of s***” and that her therapist had warned her not to focus on the presidential candidate.

“Well, I would rather give birth to a flaming iguana while taking a s***,” she said. “I hate him. I hate him.”

O'Donnell and Trump have been feuding for nearly a decade.

After news broke that O'Donnell was engaged to marry her now ex-wife Michelle Rounds, Trump tweeted: “I feel sorry for Rosie's new partner in love whose parents are devastated at the thought of their daughter being with @Rosie – a true loser.”

O'Donnell delivered her one-liners at a Boy George concert, which also included an appearance by Cyndi Lauper.