Jeffrey Tambor has called the upcoming comedy-drama Transparent a “game changer.”

In the 10-episode original series created and directed by Jill Soloway (Six Feet Under, United States of Tara), Tambor plays Moira, a transgender woman. Moira's adult children are played by Gaby Hoffmann, Jay Duplass and Amy Landecker, whose character is either bisexual or gay.

Transparent, which will be released in its entirety on September 26, also co-stars Judith Light as Mom and Carrie Brownstein as Syd.

“This is a, it's a game changer,” Tambor told the AFP during the show's premiere party. “There's nothing like this on television. … And I couldn't be more proud.”

“I loved the story,” Brownstein said. “I was excited it was for Amazon. I'm excited that people can watch it all at once.”