Premium cable network HBO has released a second trailer for the upcoming film adaptation of The Normal Heart, Larry Kramer's Tony-winning AIDS play.

The film, which HBO will premiere Sunday, May 25, features an all-star cast, including Mark Ruffalo, Matt Bomer, Taylor Kitsch, Jim Parsons and Julia Roberts.

Ryan Murphy (Glee, Eat Pray Love) directed the feature length film, which is based on a script written by Larry Kramer (Women in Love).

Ruffalo – a co-star of the 2010 lesbian moms flick The Kids Are Alright – will tackle his first gay role playing Ned Weeks, the hero of Kramer's play about the early days of the AIDS pandemic in New York City.

In the 45-second trailer, Roberts' character of Dr. Emma Brookner declares: “I've never seen or heard of anything like this.”

In another shot, Weeks is seen being carted away from City Hall screaming: “This is lunacy. You must of heard about it. We need your help badly.” (The video is embedded on this page. Visit our video library for more videos.)