Matthew McConaughey's performance playing a homophobe who acquires HIV in the Dallas Buyers Club is generating an Oscar buzz.

The film, which premiered at the Toronto Film Festival, also stars Jared Leto as Rayon, an HIV-positive transgender woman.

The film is loosely based on the life of Ron Woodroof, a foulmouthed womanizer who in 1986 was diagnosed with HIV/AIDS and given 30 days to live. He was prescribed AZT, the only legal drug available at the time in the United States, but the drug's side effects brought Woodroof to the brink of death. With the help of his doctor, Eve Saks (played by Jennifer Garner) and Rayon, Woodroof created the nation's first club selling alternative and experimental treatments to combat HIV/AIDS. He died in 1992, 2,161 days later than doctors had anticipated.

In the process of attempting to save his own life, Woodroof took on the medical establishment and the FDA. (The trailer is embedded on this page. Visit our video library for more videos.)

McConaughey, who lost nearly 50 pounds for the role, personally championed the film's production.